Skip to main content

CMLpaed registry

CMLpaed Registry

CML is a rare form of leukemia among children and adolescents, but one of the common hematological diseases in older age. A number of clinical findings in pediatric CML suggest differences of leukemia cell or host biology compared with CML in adults. Aim of the clinical CMLpaed registry and the accompanying research projects is to understand the age dependent molecular and cellular features of the disease and their impact on the clinical management



Meinolf Suttorp
Medical Faculty, Pediatric Hemato-Oncology, Technical University Dresden         
Gudrun Göhring, Anke Bergmann, Brigitte Schlegelberger
Department of Human Genetics, Hannover Medical School
Ingmar Glauche, Ingo Röder
Institute for Medical Informatics and Biometry,
Faculty of Medicine Carl Gustav Carus, TU Dresden
Daniela Krause, Georg-Speyer-Haus
Institute for Tumor Biology and Experimental Therapy, Frankfurt
Frederic Millot
Pediatric Oncology Unit, University Hospital, Poitiers, France

Selected publications

Large amplicon droplet digital PCR for DNA-based monitoring of pediatric chronic myeloid leukaemia.
Krumbholz M, Goerlitz K, Albert C, Lawlor J, Suttorp M, Metzler M. J Cell Mol Med. 2019 Aug;23(8):4955-4961

Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial.
Suttorp M, Schulze P, Glauche I, Göhring G, von Neuhoff N, Metzler M, Sedlacek P, de Bont ESJM, Balduzzi A, Lausen B, Aleinikova O, Sufliarska S, Henze G, Strauss G, Eggert A, Kremens B, Groll AH, Berthold F, Klein C, Groß-Wieltsch U, Sykora KW, Borkhardt A, Kulozik AE, Schrappe M, Nowasz C, Krumbholz M, Tauer JT, Claviez A, Harbott J, Kreipe HH, Schlegelberger B, Thiede C.Suttorp M, et al. Leukemia. 2018 Jul;32(7):1657-1669.

Pediatric chronic myeloid leukemia is a unique disease that requires a different approach.
Hijiya N, Schultz KR, Metzler M, Millot F, Suttorp M.Hijiya N, et al. Blood. 2016 Jan 28;127(4):392-9.

DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia.
van der Sligte NE, Krumbholz M, Pastorczak A, Scheijen B, Tauer JT, Nowasz C, Sonneveld E, de Bock GH, Meeuwsen-de Boer TG, van Reijmersdal S, Kuiper RP, Bradtke J, Metzler M, Suttorp M, de Bont ES, van Leeuwen FN.van der Sligte NE, et al. Br J Haematol. 2014 Jul;166(2):250-3.