Molecular mechanisms determining ctDNA release

Molecular mechanisms determining release of circulating tumor DNA in the blood stream during tumor growth and therapeutic intervention are only partially understood. We examine tumor tissue as well as the surrounding tumor microenvironment in a Ewing sarcoma mouse model. These findings contribute to a better interpretation of ctDNA levels in our patients throughout the course of therapy. We further want to define interactions of tumor tissue and microenvironment to exploit as an additional treatment option.